Our laboratory investigates the origin, development, and differentiation of hematopoietic stem cells (HSCs) to treat patients with leukemia, lymphoma, genetic blood disorders, and bone-marrow failure syndromes. We have expertise in utilizing zebrafish, mice, and human induced pluripotent stem (iPS) cells to clone and analyze novel genes and mechanisms important for blood formation. Our goal is to utilize our knowledge in developing mechanism-based therapies as well as generating functional HSCs from patient-derived tissues for the treatment of hematological diseases using state-of-the-art gene-editing, cell-engineering, and computational approaches.


We are grateful to the National Institute of Health, the St. Baldrick's Foundation, the American Society of Hematology, and the Cooley’s Anemia Foundation for sponsoring our research endeavors.